SFN, one of the best characterized ITC present in high concentrations in broccoli, decreased phosphorylation of Akt and S6K1 in MDA-MB-231, MCF-7, MDA-MB- 468 and SKBR-3 breast cancer cell lines [23] and inhibited Akt and mTOR pathway in acute lymphoblastic leukemia cells [22]. The gene discussed is AKT1; the disease is breast carcinoma.