ITGAM and neoplasm: As demonstrated in Fig. 5a, cellular markers of antitumor immune cells such as natural killer cells (NK1.1-positive cells) and antigen presenting cells (monocyte/macrophages and dendritic cells; CD11b-positive cells) were abundantly infiltrated into tumor tissues of mice treated with Ad-ΔB/TRAIL plus Ad-ΔB/IL-12 compared with therapy with Ad-ΔB (Fig. 5a).