TNFSF10 and neoplasm: Interestingly, our results showed that OAd-mediated simultaneous delivery of TRAIL and IL-12 genes elicited profound anti-HCC tumouricidal effects both in vitro and in vivo; and it was closely associated with enhanced apoptosis promotion, activation of anti-tumor immunity and inhibition of tumor angiogenesis and vasculature, than those mediated by non-armed control OAd lacking the therapeutic genes.