Our findings demonstrated that both NK1.1-and CD11b-positive cells were abundantly infiltrated into tumor tissues of mice treated with Ad-ΔB/TRAIL plus Ad-ΔB/IL-12 compared with therapy with Ad-ΔB or PBS, and this effect was also accompanied with a remarkable upregulation in intratumoral IFN-γ production; reflecting that dual therapy with OAds co-expressing TRAIL andIL-12 is significantly associated with generation of anti-tumour specific immune response. The gene discussed is SPRR2A; the disease is neoplasm.