TNFSF10 and hepatocellular carcinoma: In agreement with our findings, He et al. [27] have previously demonstrated that combination of recombinant TRAIL and IL-12 significantly sensitizes HCC cells to TRAIL’s apoptotic effect, and similarly Cai et al. [14] have elucidated the synergistic antitumor effect of TRAIL with another immunostimulant cytokine, IL-24, in eradication of subcutaneous xenograft model of hepatoma induced by BEL7404 cells.