In addition, we examined the morphological changes in the liver tissues of HCC-bearing mice following systemic treatment with PBS, Ad-ΔB, or Ad-ΔB/TRAIL + Ad-ΔB/IL-12 (1 × 1010 VP, three times every other day) for further assessment of Ad-induced hepatotoxicity. This evidence concerns the gene TNFSF10 and hepatocellular carcinoma.