TNFSF10 and hepatocellular carcinoma: Therefore, in the present study we generated two OAds armed with human TRAIL and IL-12 gene (Ad-ΔB/TRAIL and Ad-ΔB/IL-12, respectively) and their combination therapy was assessed both in vitro on human HCC cell lines and in vivo on an orthotopic human HCC model induced in the liver lobules of nude mice.