TNFRSF13B and Autoimmunity: The disappearance of iNKT would further hinder B-cell activation and memory formation.63 It is, however, important to note that many T-cell independent mechanisms such as CLEC16A and Transmembrane activator and calcium modulator and cyclophilin ligand interactor (TACI) polymorphism may also mediate autoimmunity,64, 65 and thymic failure thus represents just one of several mechanisms for patients with CVID to develop autoimmunity.