They have highly restricted TCRs (Vα24/Vβ11) and are responsible for a range of immune responses, in particular the control of chronic viral infections.50 Using CD1d tetramers and Vα24/Vβ11 antibodies, Fulcher et al51 first demonstrated a significant reduction in iNKT among Freiberg Group 1a CVID patients. This evidence concerns the gene CD1D and common variable immunodeficiency.