In conclusion, we found in this study that two variations rs61745299 and rs35920428 in the CHIT1 gene were associated with the risk of CRC and expression levels of the CHIT1 and C-reaction protein genes in the cancer tissue, providing further evidence for the key roles of chitotriose, chitotriosidase and C-reaction protein in the intestinal inflammation and CRC pathogenesis. This evidence concerns the gene CHIT1 and colorectal carcinoma.