This trend towards a favorable prognosis in the CMS1 specific CKLF-high group was also observed in a further independent dataset (HR 0.38, 95% CI 0.13-1.13) (GSE14333 n=188, CMS1 n=41), containing a mix of colon and rectal tumor transcriptional profiles, some of which had received adjuvant chemotherapy or neo-adjuvant chemo-radiotherapy treatments regimes (Supplementary Figure 1G). The gene discussed is CKLF; the disease is rectal neoplasm.