CD4 and neoplasm: In line with our hypothesis, the depletion of both NK cells and CD8+ T cells together had the greatest effect in reducing the survival time in this tumor model (combo 24 days, α-CD4 31 days, α-CD8 35 days, Asialo 27 days, Clodrolip 43 days, IgG2a control > 100 days), suggesting that a synergistic effect may be occurring.