In APEX1 rs3136817, compared to the TT genotype and T allele, TC genotype and C allele were associated with a decreased risk of bladder cancer (P = 0.002, adjusted OR = 0.48, 95% CI: 0.30–0.77; P = 0.005, adjusted OR = 0.56, 95% CI: 0.38-0.84, respectively). The gene discussed is APEX1; the disease is urinary bladder carcinoma.