In XRCC1 rs3213356, compared to TT genotype, CT genotype showed a decreased risk while CC genotype showed an increased risk of bladder cancer (P = 0.002, adjusted OR = 0.43, 95% CI: 0.25–0.74; P = 0.005, adjusted OR = 5.76, 95% CI: 1.69–19.67, respectively). This evidence concerns the gene XRCC1 and urinary bladder carcinoma.