Gradually increased expressions of CUL2 mRNA was determined from HPV negative normal cervix throughout HPV16 positive normal cervix and HPV16 positive CIN2-3 to HPV16 positive cervical cancer tissues, with an increase of 1.64-fold (p = 0.047), 3.77-fold (p = 7.73×10−10), and 7.98-fold (p = 6.75×10−11), respectively, compared to HPV negative normal cervical tissues (Figure 1A). Here, CUL2 is linked to cervical cancer.