CUL2 and cervical carcinoma: To confirm CUL2 function in HPV16 induced carcinogenesis, we observed the influence of CUL2 on tumorigenicity and growth of cervical cancer in vitro and in vivo by loss-of-function experiments, and found that enforced inhibition of CUL2 expression evidently suppressed cell proliferation through retarding G1-S transition of cell cycle and inducing early apoptosis in cervical cancer cells.