E2F1 and cervical cancer: Furthermore, E2F1-Chromatin immunoprecipitation (ChIP) specificity also showed that E2F1 suppression by E2F1 siRNA resulted in reduced E2F1 occupation on the miR-424 promoter (Figure 4F) Thus, our results suggest that E2F1 functions as a transcriptional repressor of miR-424 in cervical cancer cells.