For the CDH13 gene association with breast cancer risk, our findings demonstrate that the frequency of CDH13 promoter methylation in cancer was OR = 13.73, 95%CI: 8.09~23.31, z = 9.70, p<0.0001 by the fixed effect model and OR = 14.23, 95%CI: 5.06~40.05, z = 5.031, p<0.0001 by the random effect model, which suggests a statistically significant increase in the likelihood of CDH13 promoter methylation in breast cancer compared to the controls. Here, CDH13 is linked to cancer.