Utilizing the extracellular region common to both truncated EGFRvIII and wild type EGFR as an antigen, antibodies that can bind both EGFRvIII and wild-type EGFR are being used as the basis of bi-specific immunotoxins to target diverse cancers with either EGFR amplification or EGFRvIII expression. This evidence concerns the gene EGFR and cancer.