In GBM, previous studies showed enhanced REST protein levels in patient-derived specimens and tumorigenic-competent GBM cells [9], and inhibition of REST in GBM isolated cancer stem cells and subsequent implantation of these cells into mice resulted in tumors that were significantly less invasive, highly apoptotic and slower growing [10,11,12], partly through regulating tumor suppressor microRNA miR-124a and its downstream targets [13]. The gene discussed is REST; the disease is cancer.