INS and type 2 diabetes mellitus: Several effective drugs are available for the treatment of T2D with the generic metformin, sulfonylureas and thiazolidinediones and novel drugs, like Dipeptidyl peptidase-4 inhibitors (DPP-4i), Sodium-dependent glucose transporter inhibitors (SGLT2i), injectable Glucagon-like peptide-1 analogues (GLP-1a) or insulin.