At 25 days after injection of HepG2 cells that were transfected with siRNA-TM4SF1, tumor expression of MMP-2, MMP-9, and VEGF were significantly lower, but tumor expression of caspase-3, caspase-9, and TIMP were higher, relative to injection with control cells (p < 0.01 for all comparisons) (Figure 5G,H). Here, TIMP1 is linked to neoplasm.