In addition, TM4SF1 overexpression is also involved in the formation of pseudopodia in cancer cells, and this facilitates the invasion and metastasis of cancer cells [31,32], and TM4SF1 has recently been reported to stimulate breast cancer cell invasion and migration through PI3K/AKT/mTOR pathway [33]. The gene discussed is TM4SF1; the disease is breast carcinoma.