Although HCV RNA levels in SR-KO, LD-KO and SR/LD-DKO Huh7 cells were lower than those in parental Huh7 cells at 24 h post-infection with HCVcc at an MOI of 1, exogenous expression of either SR-B1 or LDLR enhanced the RNA in SR-KO, LD-KO and SR/LD-DKO Huh7 cells to levels comparable to those in parental cells. The gene discussed is SCARB1; the disease is infection.