Although CD81 KO Huh7 cells did not show any susceptibility to HCVpp infection, the infectivity of HCVpp to SR/LD-DKO Huh7 cells was comparable to that in SR/LD-DKO Huh7 cells expressing lipoprotein receptor, suggesting that viral particle-associated lipoproteins participate in the lipoprotein receptor-mediated HCV entry. Here, CD81 is linked to infection.