PGP and cancer: For example, some lignans, such as gomisin A, gomisin G, Schizandrin, and schisanhenol were recently reported to possess valuable anti-tumor promoting bioactivities by inhibiting Epstein-Barr virus early antigen (EBV-EA) activation[44], reversing P-glycoprotein-mediated multidrug resistance (Pgp-MDR) in cancer cells [45], and enhancing doxorubicin-induced apoptosis in human hepatic cancer cells, as well as through the inhibition of platelet aggregation and anti-HIV (human immunodeficiency virus) effects [46, 47].