Protein catabolism machineries were previously found as most significantly dysregulated in OPMD [25], and therefore here we focus on genes of these networks including: E3-ligases: Atrogin-1, Murf1, Arih1, Arih2, Rbx1; proteasome associated genes: Psme3, Psmd14, Rad23a, Ubqulin1; and autophagy related genes: Atg10, Atg12. Here, PSME3 is linked to oculopharyngeal muscular dystrophy.