As EGFR phosphorylation/activation mediates mucin expression in response to other respiratory viruses, RSV A2 is known to activate EGFR, and RSV 2–20 F is more “mucogenic” than A2 F in the context of infection, we hypothesized that the 2–20 strain F protein potently activates EGFR. Here, MUC5AC is linked to infection.