MAPT and memory impairment: OA, a phosphatase 2A inhibitor, has been used widely to induce hyper-phosphorylation of tau in order to stimulate neural death in culture and enhance Aβ deposition, synaptic loss, as well as memory impairment in AD animal models (Barrio et al., 2011[3]; Li et al., 2011[33]; Kamat et al., 2013[27]).