In a separate study by Bai et al., proteome analysis in the CSF of NMO patients in comparison to control group revealed the up regulation of Neurofilament, Haptoglobin, immunoglobulin kappa chain C region (IGKC) and immunoglobulin heavy chain gamma 3 (IGHG3) levels [102]. The gene discussed is IGKC; the disease is neuromyelitis optica.