ABCB7 and myelodysplastic syndrome with ring sideroblasts: Although altered expression of some of these genes, including down-regulation of ABCB7 and up-regulation of ALAS2, had been known to be present in RARS (Boultwood et al. 2008; Nikpour et al. 2010) for some time, mutations in the genes found in congenital SA have not been described in MDSs.