CEP290 and Leber congenital amaurosis: Optical coherence tomography (OCT) analysis has shown that CEP290-LCA patients often retain central retina structure and that photoreceptor ONL thickness is normal in the cone-rich fovea, but severely reduced toward the rod-rich peripheral retina (Boye et al., 2014, Cideciyan et al., 2007, Pasadhika et al., 2010).