This suggests that the therapeutic window for CEP290-LCA caused by this intronic change might be longer than previously estimated and that photoreceptors might be more amenable to gene-directed therapies aimed at correcting splicing such as that described here, especially given that CEP290 is too big for conventional AAV gene therapy (Allocca et al., 2008). Here, CEP290 is linked to Leber congenital amaurosis.