CEP290-MO-treated LCA optic cups had significantly increased levels of the correctly spliced exon 26-27 transcript, increasing to over 50% of the total transcript in LCA line 1 (Figure 5C) and up to 70% in LCA line 2 (Figures S7A and S7B). The gene discussed is CEP290; the disease is Leber congenital amaurosis.