Similarly in AD, dephosphorylated BAD protein causes mitochondrial dysfunction20 thereby inducing apoptosis through Apoptosis regulator Bcl-2 (BCL2) mediated proteins such as CASP321, 22, CASP823, 24, PSEN125, 26, PIN127, 28, TP53BP229, 30, ITM2B31, 32 and results in APP formation that contributes in the pathogenesis of Alzheimer’s disease in the early stage. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.