Multivariate logistic regression analysis of the factors significantly associated with arterial stiffness (age, DM, HTN, SBP, DBP, pulse pressure, and leptin) showed that leptin (P = 0.037), age (P = 0.002), and DM (P = 0.023) were independent predictors of arterial stiffness (Table 3). The gene discussed is LEP; the disease is diabetes mellitus.