TDP-43 forms pathological cytoplasmic inclusions in affected brain tissues of nearly all sporadic and familial ALS cases, with the exception of SOD1-associated forms, and of a subset of patients with FTD (FTD-TDP), representing an important molecular link between these two apparently different neurodegenerative disorders [29]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.