Our data also suggest that mutant TARDBP and C9ORF72 trigger mitochondria alterations in response to energy demand in a specific manner because mitochondrial morphological changes were not present in mutant SOD1 and sporadic ALS fibroblasts when they were similarly exposed to oxidative conditions in galactose-containing medium [4, 5]. The gene discussed is SOD1; the disease is amyotrophic lateral sclerosis.