Major hub genes in this module are ZRANB2, TMEM126B, RPL15, PCNP and SRP9. The genes with highest MDD gene significance are LOC1001291, ANXA1, RNF13, GMFG and H3F3B. For childhood ADHD these are SUMO3, RPL22, UTP3, POLE3 and CCDC50. The gene discussed is POLE3; the disease is attention deficit-hyperactivity disorder.