Down-regulation of miR-223 has been verified in several HCC studies [47, 48] and its down-regulation is associated with the epigenetic regulation by highly expressed sulfatide and involved in tumor metastasis; and the regulatory role of miR-223 in hepatocarcinogenesis may involve modulation of several targets including integrin αV and c-myc [12, 37]. Here, MYC is linked to hepatocellular carcinoma.