Studies have confirmed that the childhood ALL regimen improves survival in AYA patients with ALL because the cumulated doses of vincristine, steroids and asparaginase in the childhood ALL regimen (e.g., BFM-90) are significantly higher than in adult regimens (e.g., ECOG E2993 or hyper-CVAD). The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.