Supplementary Figure 3 illustrates a comparison of rankings of the minimal depth and variable importance. Both minimal depth and variable importance indicate a strong relation of age and type of melanoma variables to the forest prediction. The accuracy of predicting the correct BRAF status in this model was 0.7171 (95% CI: 0.6903–0.7428) with a sensitivity of 0.8445 and a specificity of 0.55545 (Table 3). Here, BRAF is linked to melanoma.