Indeed, IRF8 deficiency in mice is characterised by the massive accumulation of immature myeloid cells promoting the development of a chronic myelogenous leukemia-like phenotype51 and in humans, loss of function of IRF8 leads to monocytic and dendritic cell immunodeficiency53. This evidence concerns the gene IRF8 and chronic myelogenous leukemia, BCR-ABL1 positive.