Featured in this list were members of the WNT (BCL9L and TCF7), RAS (PRKCQ, MAP2K1, and MAP2K7), and TGF-β (TGIF1) signaling pathways, as well as the RNA processing machinery (RBM10 and RBM12), which were not previously found to be significantly mutated in CRC. The gene discussed is MAP2K1; the disease is colorectal carcinoma.