Featured in this list were members of the WNT (BCL9L and TCF7), RAS (PRKCQ, MAP2K1, and MAP2K7), and TGF-β (TGIF1) signaling pathways, as well as the RNA processing machinery (RBM10 and RBM12), which were not previously found to be significantly mutated in CRC. This evidence concerns the gene TGIF1 and colorectal carcinoma.