To broaden our study of the effects IFN-Is have on the level of cytokine expression in an inflammatory setting such as Salmonella-induced colitis, we examined the expression of the pro-inflammatory genes Il6 and Cxcl2, and the anti-inflammatory genes Il10 and Muc2. IL-6 and CXCL2 play important roles in macrophage activation and neutrophil function and recruitment. The gene discussed is CXCL2; the disease is colitis.