LTBP2 and glaucoma: The extremely high prevalence of glaucoma and the developmental abnormalities we identified in the aqueous outflow pathways of affected cats strongly suggest that caution should be exercised in attributing glaucoma pathogenesis in patients with LTBP2 mutations solely to lens instability, particularly as phenotypic heterogeneity has been described in human patients, even between individuals with the same mutation in LTBP2 [35].