Generalized ECM abnormalities resembling Marfan disease and Weill-Marchesani syndrome have been observed [34, 35, 51] Further, LTBP2 has been identified as a potential candidate biomarker for fracture risk [52], death associated with pulmonary disease with acute dyspnea [53] and adverse renal events in humans [54]. This evidence concerns the gene LTBP2 and lung disorder.