Higher vitamin D exposure is hypothesized to prevent several cancers, possibly through genomic effects modulated by the vitamin D receptor (VDR).3 Laboratory investigations have suggested that the expression of the VDR might be associated with an increased risk of breast cancer.4 The human VDR gene, located on chromosome 12q13, includes more than 470 single-nucleotide polymorphisms (SNPs), mostly studied SNPs as following: Fok1 (rs2228570), Bsm1 (rs1544410), Taq1 (rs731236), Apa1 (rs7975232), and Poly A (rs17878969).5 The gene discussed is ZNF410; the disease is breast carcinoma.