A gain-of-function in the melanoma stem cell marker ABCB5 is also probable because of its connection with five down-regulated UV-miRNAs (Fig 4c and S3 Table), and two of them (miR-186-5p/186 and miR-331-3p) are identical to the ones that are up-regulated in the irradiated melanocytes of healthy persons (Fig 2c). The gene discussed is ABCB5; the disease is melanoma.