Given the involvement of CXCR3 in the antigen processing and presentation pathway, which takes over the crucial position in NPC progression as mentioned previously, and its potential endogenous tumor control, it has been speculated that CXCR3 may be an essential factor contributing to the function of the nasopharynx whose dysregulation may result in carcinogenesis. This evidence concerns the gene CXCR3 and nasopharyngeal carcinoma.