PPARG and type 2 diabetes mellitus: Similar observations were made by Bagi and co-workers that pioglitazone increased NO bio-availability and reduced oxidative stress in coronary arterioles of mice with type 2 diabetes.25 Matsumoto and colleagues reported that chronic treatment with pioglitazone restored impaired NO-mediated, endotheliumdependent relaxation in diabetic rat aortae.26 It has been shown that reduction in blood pressure in the case of STZ-induced diabetic rats was NO mediated.4 Calnek and co-workers reported that PPARgamma agonists increased NO bioavailability in cultured cells.27