Notwithstanding, 14/90 patients in this case series developed cardiac arrhythmia or cardiac arrest, a number of them did not have any EKG changes on their initial presentation.[32] Sixth, the three studies that used the infusion of 20 units of insulin over 60 minutes, reported data on plasma K+ up to only 60 minutes. This evidence concerns the gene INS and chronic obstructive pulmonary disease.