INS and Hypoglycemia: It has a crucial role in pancreatic β-cell membrane repolarization and its function.3, 4, 9 The fact that Kv2.1 inhibition promotes insulin secretion in response to high glucose implies the possibility in avoiding the side effect of hypoglycemia.28, 29 Besides, Kv2.1 also functions potently in the regulation of cell apoptosis although the underlying mechanisms have not yet been unveiled.7