CLU and Autoimmunity: Defects in apoptotic cell clearance and/or an excess of apoptotic cells make mice and humans susceptible to autoimmunity.28 Although efferocytosis is mediated by multiple and partly redundant mechanisms to avoid the initiation of an autoimmune response, it has been reported that repeated injections of apoptotic cells may induce signs of autoimmunity (without clinical signs).49 Considering the role of Clu in efferocytosis, we hypothesized that an excess of apoptotic cells could be less efficiently cleared in Clu−/− mice, leading to a more intense immune response.