We compared, in Clu−/− and WT mice, the appearance of signs of autoimmunity in a model of mild autoimmune response induced by repeated injections of apoptotic cells.47, 49 Results showed that, 2 weeks after the first injection of apoptotic cells, the levels of IgG anti-dsDNA Ab were increased in Clu−/− mice compared with WT mice (2638 U/ml±282 versus 1823 U/ml±450, respectively; Figure 6a). The gene discussed is CLU; the disease is Autoimmunity.