Nrf2 regulates ROS production by mitochondria and NADPH oxidase,37 and accumulation of Nrf2 in cancer cells offers protection against oxidative stress and chemotherapeutic agents.38 Besides, inhibition of Nrf2 enhances sensitivity to chemotherapeutics.39 It is possible that decreased Nrf2 level induced upon pharmacological inhibition or siRNA-mediated knock-down of TERT triggers ROS production to induce cell death. Here, FMO5 is linked to cancer.