Here we extend these findings to models of diabetic retinopathy, as well as spontaneous CNV, akin to wet AMD, which unlike the glaucoma model have VEGF-driven pathology.9, 11 We used Ins2Akita diabetic mice, which have elevated levels of apoptotic nuclei in the ganglion cell layer (GCL) (Supplementary Figure S1A; P<0.01). The gene discussed is VEGFA; the disease is age-related macular degeneration.