We initially investigated this in models of ischemia–reperfusion injury,6 then ocular hypertension (OHT), to parallel a disease scenario where VEGF-A antagonists are used in the clinic, namely for neovascular glaucoma, or as an adjunct to trabeculectomy surgery.7 We found in both models that exogenously injected VEGF-A was protective, but also VEGF-A-neutralization exacerbated retinal damage. This evidence concerns the gene VEGFA and ocular hypertension.