Resveratrol activates the AMPK pathway and restores aging-related metabolic phenotypes by directly inhibiting PDEs.17 To evaluate the roles of PDEs in cancer growth inhibition by resveratrol, we compared the effects of resveratrol with those of the specific PDE4 inhibitor rolipram on the growth of prostate cancer PC-3 cells. This evidence concerns the gene PDE4A and Familial prostate cancer.