It was reported that AMPK inhibited the mTORC1 pathway,26 which promotes the development of prostate cancer,23 and also that resveratrol inhibited the mTORC1 pathway.7, 39 We therefore examined whether these PDE inhibitors, including resveratrol, inhibited the mTORC1 pathway. Here, ALDH7A1 is linked to Familial prostate cancer.