T-ALLs can be subclassified into early T-cell progenitor ALL (ETP-ALL), cortical T-ALL, and mature T-ALL based on stage-specific differentiation markers, with ETP-ALLs being defined by the absence of CD4, CD8, and CD1a and frequent expression of one or more myeloid markers (Coustan-Smith et al. 2009). This evidence concerns the gene CD4 and acute lymphoblastic leukemia.