BRD4 and acute myeloid leukemia: In contrast, high levels of H3K27ac marks were observed in a more distal 3′ region termed the BRD4-dependent MYC enhancer (BDME), which has been implicated in regulation of MYC in acute myeloid leukemia (AML) (Shi et al. 2013) and in GSI-resistant cortical T-ALL (Yashiro-Ohtani et al. 2014).