Lack of response of MYC to Notch inhibition can be explained by the inactivate state of the Notch-dependent MYC long-range enhancer (NDME) in this tumor, which appears instead to rely on a BRD4-dependent long-range enhancer (BDME) defined previously in AML (Shi et al. 2013). Here, BRD4 is linked to acute myeloid leukemia.