TBX20 and Arrhythmia: Ablation of Tbx20 activity in adult cardiomyocytes disrupts the structure of myofibrils and causes arrhythmia in both Drosophila and mouse models [36,43], and mutations in tbx20 are associated with diverse cardiac pathologies including cardiomyopathy in humans [43,44,45,46,47,48,49].