Cells in GBM express OCT-4 (104, 105), SOX2 (1, 104, 114), pSTAT3 (81, 134), NANOG (104, 152), SALL4 (80, 99), c-Myc (78, 168, 172), KLF4 (58, 190), nestin (20, 21), CD44 (239, 240), CD133 (21, 218), and GFAP (207, 208), highlighting an overlapping hierarchical and heterogeneous population of stem and progenitor cells within GBM. This evidence concerns the gene SOX2 and glioblastoma.