Cells in GBM express OCT-4 (104, 105), SOX2 (1, 104, 114), pSTAT3 (81, 134), NANOG (104, 152), SALL4 (80, 99), c-Myc (78, 168, 172), KLF4 (58, 190), nestin (20, 21), CD44 (239, 240), CD133 (21, 218), and GFAP (207, 208), highlighting an overlapping hierarchical and heterogeneous population of stem and progenitor cells within GBM. The gene discussed is CD44; the disease is glioblastoma.