The local increase of IFN-γ modulated the status of tumor-associated macrophages (TAM) associated with the cancer microenvironment: human monocytic cell line THP-1 cells, stimulated with phorbol-12-myristate-13-acetate, differentiated to macrophages with M2-like phenotypes, which display TAM-like properties (71). This evidence concerns the gene IFNG and neoplasm.