NFKB1 and colorectal carcinoma: In colon carcinoma cancer (CRC) cells, the downregulation of NF-κB activation and its translocation to the nucleus, as well as the downregulation of gene end products regulated by NF-κB, i.e., matrix metalloproteinase (MMP)-9 and CASP 3, were both mediated through the inhibition of NF-κB inhibitor α (IκBα) kinase (43).