PTGS2 and breast cancer: In MCF-7 breast cancer, as a result, DHT inhibited several resveratrol-stimulated effects: (i) phosphorylation of Ser-15 of p53, (ii) COX-2/p53-dependent gene expression and nuclear complex of p53–COX-2 formation, essential for p53-dependent apoptosis, and (iii) p53-directed transcriptional activity (70).