EGR1 and lung adenocarcinoma: In lung adenocarcinoma cells, when combined with resveratrol, both synthetic and natural Egr-1 promoters induced the expression of the exogenous (but not the endogenous) nuclear protein called “growth arrest and DNA damage” (GADD)-45α, particularly responsive to genomic instability finally promoting apoptosis via ERK/JNK-ElK-1 pathway (50).