In hepatocellular carcinoma cells, the exocyst positions receptors at the PM such as the G-coupled chemokine receptors CXCR4 (Cepeda et al., 2015), whose overexpression is known in a range of tumor types, where it plays a central role in tumor growth and metastasis (Domanska et al., 2013). The gene discussed is CXCR4; the disease is neoplasm.