PKD2 and autosomal dominant polycystic kidney disease: However, Sec10 genetically and physically interacts with the ciliary protein polycystin-2 whose mutation leads to autosomal dominant polycystic kidney disease (ADPKD), and knock down of Sec10 causes the generation of multiple kidney cysts with short primary cilia, a hallmark of ADPKD (Fogelgren et al., 2011; Seixas et al., 2016).