FH and infection: Pathogens bind FH regions distinct from its complement inhibitory domains, information that has been used to engineer FH fusion proteins lacking complement-inhibitory activity to the Fc region of IgG and thereby exploit this virulence property as a therapeutic target to direct Fc mediated clearance of Neisseria meningitidis and Neisseria gonorrhoeae in animal models of infection (Shaughnessy et al., 2014, 2016).