Somatically altered genes or polymorphisms that are repeatedly found in CRC often affect the KRAS-, MYC-, Wnt-, mitogen-activated protein kinase (MAPK)-, or TGF-β/bone morphogenetic protein (BMP)-signaling pathways, lamina structural proteins or components of the DNA repair machinery [reviewed in Ref. Here, TGFB1 is linked to colorectal carcinoma.