On the other hand, our model well explains: (a) the discrepancy observed in CML patients between the expression of BCR/abl transcript and that of BCR/Abl protein (32) and (b) the IM resistance of CML progenitors shown to be BCR/abl-positive by FISH or PCR (33), which we believe to be in fact transcript-positive/protein-negative cells. Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.